Trends in the epidemiology of childhood tuberculosis in Greece.

TitleTrends in the epidemiology of childhood tuberculosis in Greece.
Publication TypeJournal Article
Year of Publication2012
AuthorsSyridou G, Mavrikou M, Amanatidou V, Spyridis N, Prasad PA, Papaventsis D, Kanavaki S, Zaoutis TE, Tsolia MN
JournalInt J Tuberc Lung Dis
Date Published2012 Jun
KeywordsAdolescent, Age Distribution, Age Factors, Antitubercular Agents, Child, Child, Preschool, Drug Resistance, Multiple, Bacterial, Emigrants and Immigrants, Endemic Diseases, Female, Greece, Humans, Incidence, Infant, Latent Tuberculosis, Male, Mycobacterium tuberculosis, Retrospective Studies, Time Factors, Tuberculosis, Tuberculosis, Multidrug-Resistant

SETTING: A hospital referral center for childhood tuberculosis (TB).

OBJECTIVE: To evaluate the epidemiological and clinical features of childhood TB in the Greater Athens area in the last decade.

DESIGN: We retrospectively reviewed the medical records of patients aged <14 years treated for active TB between January 2000 and December 2009 at our pediatric TB clinic and compared the results with the patient turnover during the previous decade (1990-1999). Data concerning demographic and clinical characteristics were analyzed.

RESULTS: A total of 321 children (median age 5.57 years, 157 males) with active TB were identified. About one third originated from areas where TB was previously recognized to be highly endemic. Twenty-three children (7%) had extra-pulmonary TB, and 61% of them originated from TB-endemic areas. Bacteriological confirmation was obtained in 40% of patients from whom specimens were obtained: 1 of 26 (3.8%) strains was multidrug-resistant. Most cases with drug-resistant Mycobacterium tuberculosis were noted among immigrant children. The average annual TB incidence was estimated at 5.37 per 100‚ÄČ000 for children aged <14 years in the Greater Athens area. Time trend analysis for the 20-year period revealed a significant reduction in the total number of TB cases (P = 0.002) and in TB among children from low-incidence countries (P < 0.0001).

CONCLUSIONS: In our settings, active TB is decreasing among children of Greek origin; disease epidemiology and drug resistance is influenced by the increasing influx of immigrants from areas where the disease is highly prevalent.

Alternate JournalInt. J. Tuberc. Lung Dis.
PubMed ID22507870