Tisagenlecleucel for the treatment of B cell acute lymphoblastic leukemia.

TitleTisagenlecleucel for the treatment of B cell acute lymphoblastic leukemia.
Publication TypeJournal Article
Year of Publication2018
AuthorsLeahy ABarz, Elgarten CW, Grupp SA, Maude SL, Teachey DT
JournalExpert Rev Anticancer Ther
Date Published2018 Aug 15
ISSN1744-8328
Abstract

INTRODUCTION: Cure rates for pediatric and young adult patients with refractory or recurrently relapsed acute lymphoblastic leukemia are dismal. Survival from time of relapse is typically measured in weeks to months, and standard chemotherapy and currently approved targeted therapy achieve remission in less than a third of affected patients. To date, the only definitive curative therapy has been allogeneic hematopoietic stem cell transplant (HSCT). Advances in immunotherapy, with the introduction of chimeric antigen receptor T cell therapies and the development of tisagenlecleucel, have changed the landscape. Areas covered: This review will describe the pharmacology of tisagenlecleucel and summarize the clinical evidence for its use in the treatment of multiple-relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). Also discussed are other immunotherapies for B-ALL as well as the most commonly-encountered toxicities and corresponding management strategies. Expert commentary: Early phase trials indicate that tisagenlecleucel significantly improves survival for patients with B-ALL that is refractory or in second or later relapse. In responding patients, remissions have been reported on the order of years, and thus, tisagenlecleucel may herald a dramatic shift in the treatment paradigm of this largely fatal disease.

DOI10.1080/14737140.2018.1512411
Alternate JournalExpert Rev Anticancer Ther
PubMed ID30111196