Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days.

TitleTest Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days.
Publication TypeJournal Article
Year of Publication2018
AuthorsBalamuth F, Cruz AT, Freedman SB, Ishimine PT, Garro A, Curtis S, Grether-Jones KL, Miller AS, Uspal NG, Schmidt SM, Shah SS, Nigrovic LE
Corporate AuthorsPediatric Emergency Medicine Collaborative Research Committee(PEMCRC) HSV Study Group
JournalPediatr Emerg Care
Date Published2018 Nov 12
ISSN1535-1815
Abstract

In our cohort of 20,947 infants aged 60 days or younger, cerebrospinal fluid Gram stain had a sensitivity of 34.3% (95% confidence interval, 28.1%-41.1%) and a positive predictive value of 61.4% (95% confidence interval, 52.2%-69.8%) for positive cerebrospinal fluid culture, suggesting that Gram stain alone may lead to both underdiagnosis and overdiagnosis of bacterial meningitis.

DOI10.1097/PEC.0000000000001639
Alternate JournalPediatr Emerg Care
PubMed ID30422943