Tamsulosin and spontaneous passage of ureteral stones in children: a multi-institutional cohort study.

TitleTamsulosin and spontaneous passage of ureteral stones in children: a multi-institutional cohort study.
Publication TypeJournal Article
Year of Publication2014
AuthorsTasian GE, Cost NG, Granberg CF, Pulido JE, Rivera M, Schwen Z, Schulte M, Fox JA
JournalJ Urol
Volume192
Issue2
Pagination506-11
Date Published2014 Aug
ISSN1527-3792
KeywordsAdolescent, Adrenergic alpha-1 Receptor Antagonists, Child, Cohort Studies, Female, Humans, Male, Remission, Spontaneous, Retrospective Studies, Sulfonamides, Ureteral Calculi
Abstract

PURPOSE: Tamsulosin is associated with increased passage of ureteral stones in adults but its effectiveness in children is uncertain. We determined the association between tamsulosin and the spontaneous passage of ureteral stones in children.

MATERIALS AND METHODS: We performed a multi-institutional retrospective cohort study of patients 18 years or younger who presented between 2007 and 2012 with ureteral stones up to 10 mm and who were treated with tamsulosin or oral analgesics alone. The outcome was spontaneous stone passage, defined as radiographic clearance and/or patient report of passage. Subjects prescribed tamsulosin were matched with subjects prescribed analgesics alone, using nearest neighbor propensity score matching to adjust for treatment selection. Conditional logistic regression models were used to estimate the association between tamsulosin and spontaneous passage of ureteral stones, adjusting for stone size and location.

RESULTS: Of 449 children with ureteral stones 334 were eligible for inclusion, and complete data were available for 274 patients from 4 institutions (99 receiving tamsulosin, 175 receiving analgesics alone). Following case matching, there were no differences in age, gender, weight, height, stone size or stone location between the 99 subjects prescribed tamsulosin and the 99 propensity score matched subjects prescribed analgesics alone. In the tamsulosin cohort 55% of ureteral stones passed, compared to 44% in the analgesics alone cohort (p=0.03). In multivariate analysis adjusting for stone size and location tamsulosin was associated with spontaneous passage of ureteral stones (OR 3.31, 95% CI 1.49-7.34).

CONCLUSIONS: The odds of spontaneous passage of ureteral stones were greater in children prescribed tamsulosin vs analgesics alone.

DOI10.1016/j.juro.2014.01.091
Alternate JournalJ. Urol.
PubMed ID24518765
PubMed Central IDPMC4104150
Grant ListT32 HD060550 / HD / NICHD NIH HHS / United States
T32HD060550 / HD / NICHD NIH HHS / United States