Systematic literature review on the economic, humanistic, and societal burden of heart failure in children and adolescents.

TitleSystematic literature review on the economic, humanistic, and societal burden of heart failure in children and adolescents.
Publication TypeJournal Article
Year of Publication2019
AuthorsBurch M, Nallagangula TKumar, Lochlainn ENic, Severin T, Thakur L, Jaecklin T, George AThomas, Solar-Yohay S, Rossano JW, Shaddy RE
JournalExpert Rev Pharmacoecon Outcomes Res
Date Published2019 Feb 12
ISSN1744-8379
Abstract

INTRODUCTION: Unlike the adult heart failure (HF) patient population, there is scarce of information on the overall burden of HF in the pediatric population across geographies and within different age groups. Areas covered: A systematic review aims to describe and quantify the economic, humanistic, and societal burden of pediatric (age <18 years) HF on patients and caregivers. Eighteen published studies over a period of 10-years (Jan 1 2006- May 20 2016) were identified through Embase, Medline, Cochrane Library and selected congresses. Studies from the US reported higher HF-related hospitalization-rates in infants aged <1 year (49.3%-63.9%) versus children aged 1-12 years (18.7%-30.9%) in HF diagnosed patients. Across the studies, average length of hospital-stay was 15 days, increasing to 26 days for infants. Average annual hospital charges were higher for infants (US$176,000) versus children aged 1-10 years (US$132,000) in the US. In Germany, diagnosis-related group (DRG)-based hospital-allowances per HF-case increased from €3,498 in 1995 to €4,250 in 2009. Expert opinion: To our knowledge, this is the first systematic review, which provides valuable insights into burden of HF in children and adolescents, and strengthens current knowledge of pediatric HF. However, there is a need for larger population based studies with wider geographical coverage.

DOI10.1080/14737167.2019.1579645
Alternate JournalExpert Rev Pharmacoecon Outcomes Res
PubMed ID30747011