SUPPORT and the Ethics of Study Implementation: Lessons for Comparative Effectiveness Research from the Trial of Oxygen Therapy for Premature Babies.

TitleSUPPORT and the Ethics of Study Implementation: Lessons for Comparative Effectiveness Research from the Trial of Oxygen Therapy for Premature Babies.
Publication TypeJournal Article
Year of Publication2015
AuthorsLantos JD, Feudtner C
JournalHastings Cent Rep
Volume45
Issue1
Pagination30-40
Date Published01/2015
ISSN0093-0334
KeywordsBrain Injuries, Comparative Effectiveness Research, Humans, Infant, Newborn, Infant, Premature, Intensive Care, Neonatal, Intubation, Intratracheal, Mortality, Neonatology, Oximetry, Oxygen, Parental Consent, Positive-Pressure Respiration, Randomized Controlled Trials as Topic, Research Design, Retinopathy of Prematurity, Standard of Care, Surface-Active Agents, Treatment Outcome, Truth Disclosure, Uncertainty
Abstract

The design of SUPPORT has been widely misunderstood. This confusion has driven much of the debate about the trial - and threatens the whole enterpise of comparative effectiveness research.

DOI10.1002/hast.407
Alternate JournalHastings Cent Rep
PubMed ID25530316
Grant ListUL1 RR033179 / RR / NCRR NIH HHS / United States
UL1 TR000001 / TR / NCATS NIH HHS / United States
UL1TR000001 / TR / NCATS NIH HHS / United States