Successful treatment of pulmonary mucormycosis in two pediatric hematopoietic stem cell transplant patients.

TitleSuccessful treatment of pulmonary mucormycosis in two pediatric hematopoietic stem cell transplant patients.
Publication TypeJournal Article
Year of Publication2018
AuthorsElgarten CW, Levy EM, Mattei P, Fisher BT, Olson TS, Freedman JL
JournalPediatr Transplant
Volume22
Start Pagee13270
Issue7
Paginatione13270
Date Published2018 Nov
ISSN1399-3046
Abstract

Pulmonary mucormycosis diagnosed immediately after hematopoietic stem cell transplantation frequently portends a poor prognosis. However, here we describe two cases in children that were treated successfully to highlight the efficacy of a multidisciplinary approach. Despite diagnosis in the immediate post-transplant period and requirement for ongoing immunosuppression to prevent or treat GVHD, both are long-term survivors due to early surgical debridement with transfusion support and prompt initiation of targeted antifungal therapy. In the absence of evidence-based treatment guidelines, survival of pulmonary mucormycosis is achievable even in high-risk patients with a multidisciplinary team to guide management.

DOI10.1111/petr.13270
Alternate JournalPediatr Transplant
PubMed ID30014584