Skeletal Morbidity in Children and Adolescents during and following Cancer Therapy.

TitleSkeletal Morbidity in Children and Adolescents during and following Cancer Therapy.
Publication TypeJournal Article
Year of Publication2018
AuthorsMostoufi-Moab S, Ward LM
JournalHorm Res Paediatr
Pagination1-15
Date Published2018 Nov 27
ISSN1663-2826
Abstract

Skeletal abnormalities are common in children and adolescents diagnosed and treated for a malignancy. The spectrum ranges from mild pain to debilitating osteonecrosis and fractures. In this review, we summarize the impact of cancer therapy on the developing skeleton, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life in childhood cancer survivors.

DOI10.1159/000494809
Alternate JournalHorm Res Paediatr
PubMed ID30481777