| Title | Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Ipe TS, Wilkes JJ, Hartung HD, Westhoff CM, Chou ST, Friedman DF |
| Journal | J Pediatr Hematol Oncol |
| Volume | 37 |
| Issue | 2 |
| Pagination | e135-7 |
| Date Published | 03/2015 |
| ISSN | 1536-3678 |
| Keywords | Anemia, Sickle Cell, Blood Group Incompatibility, Child, Preschool, Erythrocyte Transfusion, Humans, Isoantibodies, Male, Pain, Prognosis, Rh-Hr Blood-Group System, Transfusion Reaction |
| Abstract | A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD*DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody. |
| DOI | 10.1097/MPH.0000000000000241 |
| Alternate Journal | J. Pediatr. Hematol. Oncol. |
| PubMed ID | 25171447 |
| PubMed Central ID | PMC4333075 |
| Grant List | 5T32HD064567 / HD / NICHD NIH HHS / United States T32 HD064567 / HD / NICHD NIH HHS / United States |