The Role of Biomarkers for Diagnosis of and Therapeutic Decisions Related to Invasive Aspergillosis in Children.

TitleThe Role of Biomarkers for Diagnosis of and Therapeutic Decisions Related to Invasive Aspergillosis in Children.
Publication TypeJournal Article
Year of Publication2013
AuthorsFisher BT
JournalCurr Fungal Infect Rep
Volume7
Issue1
Pagination7-14
Date Published2013 Mar 1
ISSN1936-3761
Abstract

Invasive aspergillosis (IA) is a feared opportunistic infection for many immuncompromised children resulting in significant morbidity and mortality. Timely diagnosis based on traditional testing modalities and clinical evaluation has proven to be challenging. Assays designed to measure IA biomarkers such as galactomannan (GM) and beta-D-glucan (BG) represent a potential significant improvement in the ability to diagnose pediatric IA. However, as with any new diagnostic tool, clinicians need to be aware of the operating characteristics of these assays in order to apply them in the appropriate settings. Published adult and pediatric data regarding GM and BG testing are reviewed and guidance regarding the appropriate utility of these assays in children is offered.

DOI10.1007/s12281-012-0127-5
Alternate JournalCurr Fungal Infect Rep
PubMed ID23439763
PubMed Central IDPMC3579665
Grant ListL40 AI090933 / AI / NIAID NIH HHS / United States