Resting energy expenditure and adiposity accretion among children with Down syndrome: a 3-year prospective study.

TitleResting energy expenditure and adiposity accretion among children with Down syndrome: a 3-year prospective study.
Publication TypeJournal Article
Year of Publication2013
AuthorsHill DL, Parks EP, Zemel BS, Shults J, Stallings VA, Stettler N
JournalEur J Clin Nutr
Volume67
Issue10
Pagination1087-91
Date Published2013 Oct
ISSN1476-5640
KeywordsAdipose Tissue, Adiposity, African Continental Ancestry Group, Basal Metabolism, Body Composition, Body Fluid Compartments, Calorimetry, Indirect, Child, Child, Preschool, Cross-Sectional Studies, Down Syndrome, Female, Humans, Male, Obesity, Prospective Studies, Rest, Siblings
Abstract

BACKGROUND: Children with Down syndrome (DS) have a higher prevalence of obesity than other children. Whether this increased risk for obesity is due to a lower resting energy expenditure (REE) is controversial. Our study assessed whether (1) the REE of children with DS adjusted for fat-free mass (FFM) was lower than that of sibling controls, and (2) the changes in fat mass (FM) over 3 years were associated with FFM-adjusted baseline REE.

METHODS: This study used cross-sectional and prospective cohort designs. Four annual measurement visits were conducted with 28 children with DS and 35 sibling controls aged 3-10 years. REE and serum thyroxine (T4) were measured at baseline. Anthropometry, skinfold thickness measures, and, in a subsample, dual-energy x-ray absorptiometry (DXA) were used at each visit to calculate FM.

RESULTS: Children with DS had significantly lower REE adjusted for FFM (-78 ‚ÄČkcal/day, 95% CI: -133 to -27, P=0.003). The difference remained significant after adjustment for FM, sex and African ancestry (-49 ‚ÄČkcal/day, 95% CI: -94 to -4, P=0.03). In the longitudinal analysis, the baseline REE adjusted for baseline FFM was not predictive of FM accretion over time (P=0.8).

CONCLUSION: Children with DS have lower REE than sibling controls, but REE was not associated with changes in FM over time. The results suggest that the lower REE of children with DS does not explain their increased risk for obesity.

DOI10.1038/ejcn.2013.137
Alternate JournalEur J Clin Nutr
PubMed ID23900244
PubMed Central IDPMC3790863
Grant ListK23 RR016073 / RR / NCRR NIH HHS / United States
K23 RR16073 / RR / NCRR NIH HHS / United States
UL1-RR-024134 / RR / NCRR NIH HHS / United States