Rapid psychosocial function screening test identified treatment failure in HIV+ African youth.

TitleRapid psychosocial function screening test identified treatment failure in HIV+ African youth.
Publication TypeJournal Article
Year of Publication2012
AuthorsLowenthal ED, Lawler K, Harari N, Moamogwe L, Masunge J, Masedi M, Matome B, Seloilwe E, Gross R
JournalAIDS Care
Volume24
Issue6
Pagination722-7
Date Published2012
ISSN1360-0451
KeywordsAdolescent, Affective Symptoms, African Continental Ancestry Group, Anti-HIV Agents, Botswana, Checklist, Child, Child Health Services, Female, HIV Seropositivity, Humans, Male, Mass Screening, Medication Adherence, Prevalence, Psychological Tests, Questionnaires, Social Behavior Disorders, Treatment Failure
Abstract

Psychosocial dysfunction in older children and adolescents is common and may lead to nonadherence to HIV treatments. Poor adherence leads to HIV treatment failure and the development of resistant virus. In resource-limited settings where treatment options are typically limited to only one or two available lines of therapy, identification of individuals at highest risk of failure before failure occurs is of critical importance. Rapid screening tools for psychosocial dysfunction may allow for identification of those children and adolescents who are most likely to benefit from limited psychosocial support services targeted at preventing HIV treatment failure. The Pediatric Symptom Checklist (PSC) is used in high resource settings for rapid identification of at-risk youth. In 692 HIV-infected treated children (ages of 8-< 17 years) in Botswana, having a high score on the PSC was associated with having virologic failure (OR 1.7, 95% CI: 1.1-2.6). The PSC may be a useful screening tool in pediatric HIV.

DOI10.1080/09540121.2011.644233
Alternate JournalAIDS Care
PubMed ID22292411
PubMed Central IDPMC3345310
Grant ListK23 MH095669 / MH / NIMH NIH HHS / United States
P30 AI045008 / AI / NIAID NIH HHS / United States
P30 AI045008 / AI / NIAID NIH HHS / United States
P30 AI045008-11 / AI / NIAID NIH HHS / United States