Racial and ethnic representation in epigenomic studies of preterm birth: a systematic review.

TitleRacial and ethnic representation in epigenomic studies of preterm birth: a systematic review.
Publication TypeJournal Article
Year of Publication2020
Authors-Ris Y Collier A, Ledyard R, Montoya-Williams D, Qiu M, Dereix AE, Farrokhi MRaschid, Hacker MR, Burris HH
JournalEpigenomics
Date Published2020 Dec 02
ISSN1750-192X
Abstract

We conducted a systematic review evaluating race/ethnicity representation in DNA methylomic studies of preterm birth. PubMed, EMBASE, CINHAL, Scopus and relevant citations from 1 January 2000 to 30 June 2019. Two authors independently identified abstracts comparing DNA methylomic differences between term and preterm births that included race/ethnicity data. 16 studies were included. Black and non-Hispanic Black deliveries were well represented (28%). However, large studies originating from more than 95% White populations were excluded due to unreported race/ethnicity data. Most studies were cross-sectional, allowing for reverse causation. Most studies were also racially/ethnically homogeneous, preventing direct comparison of DNA methylomic differences across race/ethnicities. In DNA methylomic studies, Black women and infants were well represented. However, the literature has limitations and precludes drawing definitive conclusions.

DOI10.2217/epi-2020-0007
Alternate JournalEpigenomics
PubMed ID33264049