Psychological Reactance is a Novel Risk Factor for Adolescent Antiretroviral Treatment Failure.

TitlePsychological Reactance is a Novel Risk Factor for Adolescent Antiretroviral Treatment Failure.
Publication TypeJournal Article
Year of Publication2020
AuthorsLowenthal E, Matesva M, Marukutira T, Bayani O, Chapman J, Tshume O, Matshaba M, Hickson M, Gross R
JournalAIDS Behav
Date Published2020 Aug 04
ISSN1573-3254
Abstract

Psychological reactance is an aversive response to perceived threats against personal agency. For adolescents receiving HIV treatment in Botswana, we utilized a two-question, medication-specific reactance tool to assess whether: (1) verbal reminders to take medicines made adolescents want to avoid taking them, and, (2) whether adolescents felt anger when reminded to take medicines. Reactant adolescents had 2.05-fold (95% CI 1.23, 3.41) greater odds of treatment failure than non-reactant adolescents (pā€‰=ā€‰0.03). Adjusted risk of treatment failure was 14% (95% CI 3%, 28%) greater for each point elevation in reactance score (pā€‰=ā€‰0.016). Autonomy over medication-taking did not modify the association between reactance and treatment failure. Psychological reactance may be a useful interventional target for improving adolescent adherence.

DOI10.1007/s10461-020-02986-z
Alternate JournalAIDS Behav
PubMed ID32754779
Grant ListP30 AI 045008 / NH / NIH HHS / United States
P30 MH097488 / NH / NIH HHS / United States
D43 TW 009781 / NH / NIH HHS / United States
K23 MH095669 / NH / NIH HHS / United States