Title | Psychological Reactance is a Novel Risk Factor for Adolescent Antiretroviral Treatment Failure. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Lowenthal E, Matesva M, Marukutira T, Bayani O, Chapman J, Tshume O, Matshaba M, Hickson M, Gross R |
Journal | AIDS Behav |
Date Published | 2020 Aug 04 |
ISSN | 1573-3254 |
Abstract | Psychological reactance is an aversive response to perceived threats against personal agency. For adolescents receiving HIV treatment in Botswana, we utilized a two-question, medication-specific reactance tool to assess whether: (1) verbal reminders to take medicines made adolescents want to avoid taking them, and, (2) whether adolescents felt anger when reminded to take medicines. Reactant adolescents had 2.05-fold (95% CI 1.23, 3.41) greater odds of treatment failure than non-reactant adolescents (pā=ā0.03). Adjusted risk of treatment failure was 14% (95% CI 3%, 28%) greater for each point elevation in reactance score (pā=ā0.016). Autonomy over medication-taking did not modify the association between reactance and treatment failure. Psychological reactance may be a useful interventional target for improving adolescent adherence. |
DOI | 10.1007/s10461-020-02986-z |
Alternate Journal | AIDS Behav |
PubMed ID | 32754779 |
Grant List | P30 AI 045008 / NH / NIH HHS / United States P30 MH097488 / NH / NIH HHS / United States D43 TW 009781 / NH / NIH HHS / United States K23 MH095669 / NH / NIH HHS / United States |