A prospective, cohort, multicentre study of candidaemia in hospitalized adult patients with haematological malignancies.

TitleA prospective, cohort, multicentre study of candidaemia in hospitalized adult patients with haematological malignancies.
Publication TypeJournal Article
Year of Publication2014
AuthorsGamaletsou MN, Walsh TJ, Zaoutis TE, Pagoni M, Kotsopoulou M, Voulgarelis M, Panayiotidis P, Vassilakopoulos T, Angelopoulou MK, Marangos M, Spyridonidis A, Kofteridis D, Pouli A, Sotiropoulos D, Matsouka P, Argyropoulou A, Perloretzou S, Leckerman KH, Manaka A, Oikonomopoulos P, Daikos G, Petrikkos G, Sipsas NV
JournalClin Microbiol Infect
Volume20
Issue1
PaginationO50-7
Date Published2014 Jan
ISSN1469-0691
KeywordsAdolescent, Adult, Agammaglobulinemia, Aged, Aged, 80 and over, Antifungal Agents, Candida, Candidemia, Case-Control Studies, Central Venous Catheters, Female, Greece, Hematologic Neoplasms, Hospitalization, Humans, Logistic Models, Male, Middle Aged, Prospective Studies, Risk Factors, Young Adult
Abstract

Invasive candidiasis is a life-threatening infection in patients with haematological malignancies. The objective of our study was to determine the incidence, microbiological characteristics and clinical outcome of candidaemia among hospitalized adult patients with haematological malignancies. This is a population-based, prospective, multicentre study of patients ≥ 18 years admitted to haematology and/or haematopoietic stem cell transplantation units of nine tertiary care Greek hospitals from January 2009 through to February 2012. Within this cohort, we conducted a nested case-control study to determine the risk factors for candidaemia. Stepwise logistic regression was used to identify independent predictors of 28-day mortality. Candidaemia was detected in 40 of 27,864 patients with haematological malignancies vs. 967 of 1,158,018 non-haematology patients for an incidence of 1.4 cases/1000 admissions vs. 0.83/1000 respectively (p <0.001). Candidaemia was caused predominantly (35/40, 87.5%) by non-Candida albicans species, particularly Candida parapsilosis (20/40, 50%). In vitro resistance to at least one antifungal agent was observed in 27% of Candida isolates. Twenty-one patients (53%) developed breakthrough candidaemia while receiving antifungal agents. Central venous catheters, hypogammaglobulinaemia and a high APACHE II score were independent risk factors for the development of candidaemia. Crude mortality at day 28 was greater in those with candidaemia than in control cases (18/40 (45%) vs. 9/80 (11%); p <0.0001). In conclusion, despite antifungal prophylaxis, candidaemia is a relatively frequent infection associated with high mortality caused by non-C. albicans spp., especially C. parapsilosis. Central venous catheters and hypogammaglobulinaemia are independent risk factors for candidaemia that provide potential targets for improving the outcome.

DOI10.1111/1469-0691.12312
Alternate JournalClin. Microbiol. Infect.
PubMed ID23889746