Prenatal vitamin use and vitamin D status during pregnancy, differences by race and overweight status.

TitlePrenatal vitamin use and vitamin D status during pregnancy, differences by race and overweight status.
Publication TypeJournal Article
Year of Publication2015
AuthorsBurris HH, Thomas A, Zera CA, McElrath TF
JournalJ Perinatol
Date Published2015 Apr
KeywordsAdult, African Americans, Dietary Supplements, European Continental Ancestry Group, Female, Humans, Logistic Models, Multivariate Analysis, Obesity, Odds Ratio, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Prenatal Nutritional Physiological Phenomena, Prospective Studies, Vitamin D, Vitamin D Deficiency, Vitamins

OBJECTIVE: We aimed to study whether prenatal vitamin (PNV) use protects against low 25-hydroxyvitamin D (25[OH]D) levels in all women and particularly in obese and black women who are both at risk of vitamin D deficiency and poor pregnancy outcomes.

STUDY DESIGN: We studied 1019 women enrolled in a prospective study at Brigham and Women's Hospital in Boston, from 2007 to 2009. We used multivariable logistic regression to analyze associations of PNV use and odds of vitamin D deficiency defined as 25[OH]D levels <50 nmol l(-1).

RESULT: In all, 56% of black and 86% of white women reported pre- and/or postconceptional PNV use. In the first trimester, 75% of black and 19% of white women were vitamin D deficient. Lack of PNV use among black women was not associated with vitamin D deficiency (adjusted odds ratio (OR) 1.0, 95% confidence interval (CI) 0.4, 2.3) but was among white women (OR 3.5, 95% CI 2.1, 5.8) (interaction P<0.01).

CONCLUSIONS: Ongoing trials of vitamin D supplementation during pregnancy should consider potential effect modification by race/ethnicity.

Alternate JournalJ Perinatol
PubMed ID25357099
PubMed Central IDPMC4380518
Grant ListK23 ES022242 / ES / NIEHS NIH HHS / United States
K23ES022242 / ES / NIEHS NIH HHS / United States