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|Title||Prenatal vitamin use and vitamin D status during pregnancy, differences by race and overweight status.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Burris HH, Thomas A, Zera CA, McElrath TF|
|Date Published||2015 Apr|
|Keywords||Adult, African Americans, Dietary Supplements, European Continental Ancestry Group, Female, Humans, Logistic Models, Multivariate Analysis, Obesity, Odds Ratio, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Prenatal Nutritional Physiological Phenomena, Prospective Studies, Vitamin D, Vitamin D Deficiency, Vitamins|
OBJECTIVE: We aimed to study whether prenatal vitamin (PNV) use protects against low 25-hydroxyvitamin D (25[OH]D) levels in all women and particularly in obese and black women who are both at risk of vitamin D deficiency and poor pregnancy outcomes.
STUDY DESIGN: We studied 1019 women enrolled in a prospective study at Brigham and Women's Hospital in Boston, from 2007 to 2009. We used multivariable logistic regression to analyze associations of PNV use and odds of vitamin D deficiency defined as 25[OH]D levels <50 nmol l(-1).
RESULT: In all, 56% of black and 86% of white women reported pre- and/or postconceptional PNV use. In the first trimester, 75% of black and 19% of white women were vitamin D deficient. Lack of PNV use among black women was not associated with vitamin D deficiency (adjusted odds ratio (OR) 1.0, 95% confidence interval (CI) 0.4, 2.3) but was among white women (OR 3.5, 95% CI 2.1, 5.8) (interaction P<0.01).
CONCLUSIONS: Ongoing trials of vitamin D supplementation during pregnancy should consider potential effect modification by race/ethnicity.
|Alternate Journal||J Perinatol|
|PubMed Central ID||PMC4380518|
|Grant List||K23 ES022242 / ES / NIEHS NIH HHS / United States |
K23ES022242 / ES / NIEHS NIH HHS / United States