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|Title||Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Wu S, Gennings C, Wright RJ, Wilson A, Burris HH, Just AC, Braun JM, Svensson K, Zhong J, Brennan KJM, Dereix A, Cantoral A, Schnaas L, Téllez-Rojo MMaria, Wright RO, Baccarelli AA|
|Date Published||2018 01|
|Keywords||Adiposity, Body Mass Index, Child, Child, Preschool, Cohort Studies, DNA Methylation, Female, Fetal Blood, Humans, Inflammation, Interleukin-6, Interleukin-8, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Tumor Necrosis Factor-alpha, Waist Circumference|
OBJECTIVE: Maternal stress during pregnancy may influence childhood growth and adiposity, possibly through immune/inflammatory programming. We investigated whether exposure to prenatal stress and methylation in inflammation-related genes were associated with childhood adiposity in 424 mother-child pairs in Mexico City, Mexico.
METHODS: A stress index was created based on four prenatally administered stress-related scales (Exposure to Violence, Crisis in Family Systems, State-Trait Anxiety Inventory, and Edinburgh Postnatal Depression Scale). We measured weight, height, body fat mass (BFM), percentage body fat (PBF), and waist circumference in early childhood (age range, 4-6 years). Body mass index (BMI) z scores were calculated according to World Health Organization standards. DNA methylation in gene promoters of tumor necrosis factor α, interleukin 8, and interleukin 6 (IL6) in umbilical cord blood were determined by pyrosequencing.
RESULTS: An interquartile range increase in stress index (27.3) was associated with decreases of 0.14 unit in BMI z score (95% confidence interval [CI] = -0.28 to -0.005), 5.6% in BFM (95% CI = -9.7 to -1.4), 3.5% in PBF (95% CI = -6.3 to -0.5), and 1.2% in waist circumference (95% CI = -2.4 to -0.04) in multivariable-adjusted models. An interquartile range increase in IL6 methylation (3.9%) was associated with increases of 0.23 unit in BMI z score (95% CI = 0.06-0.40), 8.1% (95% CI = 2.3-14.3) in BFM, 5.5% (95% CI = 1.7-9.5) in PBF, and 1.7% (95% CI = 0.2-3.3) in waist circumference.
CONCLUSIONS: Prenatal stress was associated with decreased childhood adiposity, whereas cord blood IL6 methylation was associated with increased childhood adiposity in Mexican children.
|Alternate Journal||Psychosom Med|
|PubMed Central ID||PMC5741481|
|Grant List||T32 ES007142 / ES / NIEHS NIH HHS / United States |
R01 ES021357 / ES / NIEHS NIH HHS / United States
R00 ES020346 / ES / NIEHS NIH HHS / United States
P30 ES000002 / ES / NIEHS NIH HHS / United States
R01 ES013744 / ES / NIEHS NIH HHS / United States
R24 ES028522 / ES / NIEHS NIH HHS / United States
P30 ES023515 / ES / NIEHS NIH HHS / United States
P30 ES013508 / ES / NIEHS NIH HHS / United States
R01 ES014930 / ES / NIEHS NIH HHS / United States
R00 ES023450 / ES / NIEHS NIH HHS / United States
R01 ES020268 / ES / NIEHS NIH HHS / United States
K23 ES022242 / ES / NIEHS NIH HHS / United States
P30 ES009089 / ES / NIEHS NIH HHS / United States