Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study.

TitlePrenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsWu S, Gennings C, Wright RJ, Wilson A, Burris HH, Just AC, Braun JM, Svensson K, Zhong J, Brennan KJM, Dereix A, Cantoral A, Schnaas L, Téllez-Rojo MMaria, Wright RO, Baccarelli AA
JournalPsychosom Med
Volume80
Issue1
Pagination34-41
Date Published2018 01
ISSN1534-7796
KeywordsAdiposity, Body Mass Index, Child, Child, Preschool, Cohort Studies, DNA Methylation, Female, Fetal Blood, Humans, Inflammation, Interleukin-6, Interleukin-8, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Tumor Necrosis Factor-alpha, Waist Circumference
Abstract

OBJECTIVE: Maternal stress during pregnancy may influence childhood growth and adiposity, possibly through immune/inflammatory programming. We investigated whether exposure to prenatal stress and methylation in inflammation-related genes were associated with childhood adiposity in 424 mother-child pairs in Mexico City, Mexico.

METHODS: A stress index was created based on four prenatally administered stress-related scales (Exposure to Violence, Crisis in Family Systems, State-Trait Anxiety Inventory, and Edinburgh Postnatal Depression Scale). We measured weight, height, body fat mass (BFM), percentage body fat (PBF), and waist circumference in early childhood (age range, 4-6 years). Body mass index (BMI) z scores were calculated according to World Health Organization standards. DNA methylation in gene promoters of tumor necrosis factor α, interleukin 8, and interleukin 6 (IL6) in umbilical cord blood were determined by pyrosequencing.

RESULTS: An interquartile range increase in stress index (27.3) was associated with decreases of 0.14 unit in BMI z score (95% confidence interval [CI] = -0.28 to -0.005), 5.6% in BFM (95% CI = -9.7 to -1.4), 3.5% in PBF (95% CI = -6.3 to -0.5), and 1.2% in waist circumference (95% CI = -2.4 to -0.04) in multivariable-adjusted models. An interquartile range increase in IL6 methylation (3.9%) was associated with increases of 0.23 unit in BMI z score (95% CI = 0.06-0.40), 8.1% (95% CI = 2.3-14.3) in BFM, 5.5% (95% CI = 1.7-9.5) in PBF, and 1.7% (95% CI = 0.2-3.3) in waist circumference.

CONCLUSIONS: Prenatal stress was associated with decreased childhood adiposity, whereas cord blood IL6 methylation was associated with increased childhood adiposity in Mexican children.

DOI10.1097/PSY.0000000000000517
Alternate JournalPsychosom Med
PubMed ID28787364
PubMed Central IDPMC5741481
Grant ListT32 ES007142 / ES / NIEHS NIH HHS / United States
R01 ES021357 / ES / NIEHS NIH HHS / United States
R00 ES020346 / ES / NIEHS NIH HHS / United States
P30 ES000002 / ES / NIEHS NIH HHS / United States
R01 ES013744 / ES / NIEHS NIH HHS / United States
R24 ES028522 / ES / NIEHS NIH HHS / United States
P30 ES023515 / ES / NIEHS NIH HHS / United States
P30 ES013508 / ES / NIEHS NIH HHS / United States
R01 ES014930 / ES / NIEHS NIH HHS / United States
R00 ES023450 / ES / NIEHS NIH HHS / United States
R01 ES020268 / ES / NIEHS NIH HHS / United States
K23 ES022242 / ES / NIEHS NIH HHS / United States
P30 ES009089 / ES / NIEHS NIH HHS / United States