Prenatal salivary sex hormone levels and birth-weight-for-gestational age.

TitlePrenatal salivary sex hormone levels and birth-weight-for-gestational age.
Publication TypeJournal Article
Year of Publication2019
AuthorsSvensson K, Just AC, Fleisch AF, Sanders AP, Tamayo-Ortiz M, Baccarelli AA, Wright RJ, Tellez-Rojo MM, Wright RO, Burris HH
JournalJ Perinatol
Date Published2019 May 20
ISSN1476-5543
Abstract

OBJECTIVE: To determine whether prenatal sex hormones from maternal saliva are associated with birth-weight-for-gestational age.

STUDY DESIGN: We measured salivary progesterone, testosterone, estradiol, dehydroepiandrosterone (DHEA), and cortisone in 504 pregnant women in a Mexico City cohort. We performed linear and modified Poisson regression to examine associations of log-transformed hormones with birth-weight-for-gestational age z-scores and the risk of small-for-gestational age (SGA) and large-for-gestational age (LGA) adjusting for maternal age, sex, BMI, parity, smoking, education, and socioeconomic status.

RESULTS: In total, 15% of infants were SGA and 2% were LGA. Each interquartile range increment in testosterone/estradiol ratio was associated with a 0.12 decrement in birth-weight-for-gestational age z-score (95% CI: -0.27 to -0.02) and a 50% higher risk of SGA versus appropriate-for-gestational age (AGA) (95% CI: 1.13-1.99).

CONCLUSION: Higher salivary testosterone/estradiol ratios may affect fetal growth, and identifying the predictors of hormone levels may be important to optimizing fetal growth.

DOI10.1038/s41372-019-0385-y
Alternate JournalJ Perinatol
PubMed ID31110244
Grant ListR00ES023450 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
K23ES024803 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
K99ES027508 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
R01ES021357 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
R01ES014930 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
R01ES026033 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
R01ES021357 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
R24ES028522 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
R01ES013744 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
P30ES023515 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /
K23ES022242 / / U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) /