Title | Predictors of antiemetic alteration in pediatric acute myeloid leukemia. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Freedman JL, Faerber J, Kang TI, Dai D, Fisher BT, Huang YS, Li Y, Aplenc R, Feudtner C |
Journal | Pediatr Blood Cancer |
Volume | 61 |
Issue | 10 |
Pagination | 1798-805 |
Date Published | 2014 Oct |
ISSN | 1545-5017 |
Keywords | Adolescent, Antiemetics, Antineoplastic Agents, Child, Child, Preschool, Cohort Studies, Female, Humans, Infant, Leukemia, Myeloid, Acute, Longitudinal Studies, Male, Nausea, Retrospective Studies, Vomiting |
Abstract | BACKGROUND: Better knowledge of patient and cancer treatment factors associated with nausea/vomiting (NV) in pediatric oncology patients could enhance prophylaxis. We aimed to describe such factors in children receiving treatment for acute myeloid leukemia (AML). METHODS: Retrospective longitudinal cohort study of 1,668 hospitalized children undergoing treatment for AML from the Pediatric Health Information System database (39 hospitals, 1999-2010). Antiemetic alteration, which included switch (a change in prescribed 5-HT₃ receptor antagonists) and rescue (receipt of an adjunct antiemetic), were first validated and then used as surrogates of problematic NV. Logistic and negative binomial regression modeling were used to test whether patient characteristics were associated with problematic NV. RESULTS: Increasing age is associated with greater odds of experiencing antiemetic switch and higher relative rate of antiemetic rescue. Within a treatment cycle, each consecutive inpatient chemotherapy day decreased the likelihood of requiring antiemetic alteration. Each consecutive inpatient-day post-chemotherapy was associated with decreased need for switch, but increased need for rescue. Subsequent cycles of AML therapy were associated with lower odds of antiemetic switch on both chemotherapy and non-chemotherapy days, a lower rate of antiemetic rescue on chemotherapy days, and an increased rate of rescue on non-chemotherapy days. CONCLUSION: In pediatric patients with AML, increasing age is strongly associated with greater antiemetic alteration. Antiemetic alteration occurs early in treatment overall, and early within each admission. While additional cycles of therapy are associated with less alteration overall, there is persistent rescue in the days after chemotherapy, suggesting additional etiologies of NV in pediatric cancer patients. |
DOI | 10.1002/pbc.25108 |
Alternate Journal | Pediatr Blood Cancer |
PubMed ID | 24939039 |
PubMed Central ID | PMC4141025 |
Grant List | 1R01HS018425 / HS / AHRQ HHS / United States P30 CA016520 / CA / NCI NIH HHS / United States T32 HD064567 / HD / NICHD NIH HHS / United States T32HD064567 / HD / NICHD NIH HHS / United States |