Predictive Validity of a Computerized Battery for Identifying Neurocognitive Impairments Among Children Living with HIV in Botswana.

TitlePredictive Validity of a Computerized Battery for Identifying Neurocognitive Impairments Among Children Living with HIV in Botswana.
Publication TypeJournal Article
Year of Publication2022
AuthorsVan Pelt AE, Moore TM, J Scott C, Phoi O, Mbakile-Mahlanza L, Morales KH, Gur RC, Rampa S, Matshaba M, Lowenthal ED
JournalAIDS Behav
Date Published2022 Feb 19
ISSN1573-3254
Abstract

Children living with HIV (HIV+) experience increased risk of neurocognitive deficits, but standardized cognitive testing is limited in low-resource, high-prevalence settings. The Penn Computerized Neurocognitive Battery (PennCNB) was adapted for use in Botswana. This study evaluated the criterion validity of a locally adapted version of the PennCNB among a cohort of HIV+ individuals aged 10-17 years in Botswana. Participants completed the PennCNB and a comprehensive professional consensus assessment consisting of pencil-and-paper psychological assessments, clinical interview, and review of academic performance. Seventy-two participants were classified as cases (i.e., with cognitive impairment; N = 48) or controls (i.e., without cognitive impairment; N = 24). Sensitivity, specificity, positive predictive value, negative predictive value, and the area under receiver operating characteristic curves were calculated. Discrimination was acceptable, and prediction improved as the threshold for PennCNB impairment was less conservative. This research contributes to the validation of the PennCNB for use among children affected by HIV in Botswana.

DOI10.1007/s10461-022-03620-w
Alternate JournalAIDS Behav
PubMed ID35182282
Grant ListF31 HD101346 / HD / NICHD NIH HHS / United States
R01 HD095278 / HD / NICHD NIH HHS / United States