- Research Methods &
- Research Training
- Research Into
|Title||Patient-reported Outcomes across Categories of Juvenile Idiopathic Arthritis.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Taxter AJ, Wileyto EP, Behrens EM, Weiss PF|
|Date Published||2015 Oct|
OBJECTIVE: Although there is increasing reliance on patient-reported outcomes (PRO) for disease management, there is little known about the differences in PRO across juvenile idiopathic arthritis (JIA) categories. The purpose of our study was to assess PRO across JIA categories, including pain, quality of life, and physical function, and to determine clinical factors associated with differences in these measures across categories.
METHODS: This was a longitudinal cohort study of patients with JIA at a tertiary care pediatric rheumatology clinic. Subjects, PRO, and clinical variables were identified by querying the electronic medical record. Mixed-effects regression assessed pain, quality of life, and function.
RESULTS: Subjects with enthesitis-related arthritis (ERA) and undifferentiated JIA had significantly more pain, poorer quality of life, and poorer physical function. The ERA and undifferentiated JIA categories, physician's global disease activity assessment, female sex, and nonsteroidal antiinflammatory drug use were significantly associated with more pain, poorer quality of life, and poorer function. In models limited to ERA, female sex and tender enthesis count were significant predictors of decreased function.
CONCLUSION: ERA and undifferentiated JIA categories had poorer PRO than other JIA categories. Further work is needed to address ways to improve PRO in children with JIA, with a special focus on children with ERA and undifferentiated JIA.
|Alternate Journal||J. Rheumatol.|
|PubMed Central ID||PMC4592479|
|Grant List||1K23AR05974901A1 / AR / NIAMS NIH HHS / United States |
5T32HD645674 / HD / NICHD NIH HHS / United States
K23 AR059749 / AR / NIAMS NIH HHS / United States
T32 HD064567 / HD / NICHD NIH HHS / United States
UL1 RR024134 / RR / NCRR NIH HHS / United States
UL1 TR000003 / TR / NCATS NIH HHS / United States
UL1RR024134 / RR / NCRR NIH HHS / United States
UL1TR000003 / TR / NCATS NIH HHS / United States