| Title | Outcomes associated with surfactant in more mature and larger premature infants with respiratory distress syndrome. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Jackson W, Taylor G, Bamat NA, Zimmerman K, Clark R, Benjamin DK, Laughon MM, Greenberg RG, Hornik CP |
| Journal | J Perinatol |
| Date Published | 2020 Feb 20 |
| ISSN | 1476-5543 |
| Abstract | OBJECTIVE: Examine the effect of off-label surfactant on mortality and morbidity in more mature and larger premature infants diagnosed with respiratory distress syndrome (RDS). STUDY DESIGN: Cohort study of premature infants born at 30-36 weeks, birth weight > 2 kg, and a diagnosis of RDS. We compared the odds of mortality and morbidity between infants who were exposed vs unexposed to surfactant. We used a treatment effects model to balance covariates between groups. RESULTS: Of 54,964 included infants, 25,278 (46%) were exposed to surfactant. The frequency of mortality and morbidities were higher in the exposed group in unadjusted analyses. Following adjustment with a doubly robust treatment effects model, we found no significant treatment effect of surfactant on mortality or morbidity. CONCLUSION: Surfactant exposure is not associated with reduced or increased mortality or morbidity in more mature premature infants with RDS. |
| DOI | 10.1038/s41372-020-0625-1 |
| Alternate Journal | J Perinatol |
| PubMed ID | 32080333 |