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|Title||Outcomes associated with surfactant in more mature and larger premature infants with respiratory distress syndrome.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Jackson W, Taylor G, Bamat NA, Zimmerman K, Clark R, Benjamin DK, Laughon MM, Greenberg RG, Hornik CP|
|Date Published||2020 Feb 20|
OBJECTIVE: Examine the effect of off-label surfactant on mortality and morbidity in more mature and larger premature infants diagnosed with respiratory distress syndrome (RDS).
STUDY DESIGN: Cohort study of premature infants born at 30-36 weeks, birth weight > 2 kg, and a diagnosis of RDS. We compared the odds of mortality and morbidity between infants who were exposed vs unexposed to surfactant. We used a treatment effects model to balance covariates between groups.
RESULTS: Of 54,964 included infants, 25,278 (46%) were exposed to surfactant. The frequency of mortality and morbidities were higher in the exposed group in unadjusted analyses. Following adjustment with a doubly robust treatment effects model, we found no significant treatment effect of surfactant on mortality or morbidity.
CONCLUSION: Surfactant exposure is not associated with reduced or increased mortality or morbidity in more mature premature infants with RDS.
|Alternate Journal||J Perinatol|