Mental Health, Social Influences, and HIV Pre-exposure Prophylaxis (PrEP) Utilization Among Men and Transgender Individuals Screening for HIV Prevention Trials.

TitleMental Health, Social Influences, and HIV Pre-exposure Prophylaxis (PrEP) Utilization Among Men and Transgender Individuals Screening for HIV Prevention Trials.
Publication TypeJournal Article
Year of Publication2020
AuthorsWood SM, Morales KH, Metzger D, Davis A, Fiore D, Petsis D, Barnett K, Koenig HC, Dowshen N, Gross R, Frank I
JournalAIDS Behav
Date Published2020 Aug 28
ISSN1573-3254
Abstract

The effects of mental health comorbidities and social support on the HIV pre-exposure prophylaxis (PrEP) care continuum are unknown. We conducted a cross-sectional study of men and transgender individuals, ≥ 18 years-old, with ≥ 2 male or transgender partners, or recent condomless anal intercourse. Surveys assessed demographics, mental health treatment, depressive symptomatology, social support, and PrEP-related social contacts. Logistic regression assessed associations between these factors and PrEP uptake and persistence. Participants (n = 247) were 89% cis-male and 46% African-American. Median age was 27 (IQR:23-33). Thirty-seven percent had ever used PrEP, of whom 18% discontinued use. High depressive symptomology was identified in 11% and 9% were receiving mental health treatment. There were no significant associations between depressive symptoms or mental health treatment on the odds of PrEP uptake or discontinuation. Each additional PrEP contact conferred a greater odds of uptake (aOR:1.24, 95% CI: 1.09-1.42). Network-level targets may produce fruitful interventions to increase PrEP uptake.

DOI10.1007/s10461-020-03004-y
Alternate JournalAIDS Behav
PubMed ID32860114
Grant ListP30 AI 045008 / / Center for AIDS Research, University of Pennsylvania /
P30 MH 097488 / / Penn Mental Health AIDS Research Center /
Pilot Grant / / CHOP Research Institute /
K23MH102128 / MH / NIMH NIH HHS / United States
K23MH119976 / MH / NIMH NIH HHS / United States
UM1 AI069534 / AI / NIAID NIH HHS / United States