Maternal anxiety and depression in pregnancy and DNA methylation of the glucocorticoid receptor gene.

TitleMaternal anxiety and depression in pregnancy and DNA methylation of the glucocorticoid receptor gene.
Publication TypeJournal Article
Year of Publication2020
AuthorsDereix AE, Ledyard R, Redhunt AM, Bloomquist TR, Brennan KJm, Baccarelli AA, Hacker MR, Burris HH
JournalEpigenomics
Date Published2020 Nov 20
ISSN1750-192X
Abstract

Aim: To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor (NR3C1). Materials & methods: Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively. NR3C1 methylation was determined at four methylation sites. Results: DNA methylation of CpG 1 in the NR3C1 CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49-4.58) and trait anxiety (β 1.68, 95% CI: 0.14-3.22). No significant association was found between depressive symptoms and NR3C1 methylation. Conclusion: We found that maternal anxiety was associated with increased NR3C1 CpG island shore methylation.

DOI10.2217/epi-2020-0022
Alternate JournalEpigenomics
PubMed ID33215541
Grant ListK23 ES022242 / ES / NIEHS NIH HHS / United States
UL1 TR001102 / TR / NCATS NIH HHS / United States