Massive cortical reorganization is reversible following bilateral transplants of the hands: evidence from the first successful bilateral pediatric hand transplant patient.

TitleMassive cortical reorganization is reversible following bilateral transplants of the hands: evidence from the first successful bilateral pediatric hand transplant patient.
Publication TypeJournal Article
Year of Publication2018
AuthorsGaetz W, Kessler SK, Roberts TPL, Berman JI, Levy TJ, Hsia M, Humpl D, Schwartz ES, Amaral S, Chang B, Levin LScott
JournalAnn Clin Transl Neurol
Volume5
Issue1
Pagination92-97
Date Published2018 Jan
ISSN2328-9503
Abstract

In this repeated measures case study, we show that sensory deafferentation after limb amputation leads to changes in cortical somatotopic maps which are reversible after restoration of sensory input. Using magnetoencephalography (MEG), we observed in a child with bilateral hand transplants large-scale shifts in somatosensory lip cortical representation from anatomic hand area to anatomic face region. After recovery of tactile sensation in the digits, responses to finger stimulation were localized to orthotopic sensory cortex, but with atypical electrophysiologic features (amplitude and frequencies).

DOI10.1002/acn3.501
Alternate JournalAnn Clin Transl Neurol
PubMed ID29376095
PubMed Central IDPMC5771315