Indoor Air Pollution Sources and Respiratory Symptoms in Bronchopulmonary Dysplasia.

TitleIndoor Air Pollution Sources and Respiratory Symptoms in Bronchopulmonary Dysplasia.
Publication TypeJournal Article
Year of Publication2020
AuthorsRice JL, McGrath-Morrow SA, Collaco JM
JournalJ Pediatr
Volume222
Pagination85-90.e2
Date Published2020 07
ISSN1097-6833
KeywordsAdolescent, Air Pollution, Indoor, Bronchopulmonary Dysplasia, Child, Child, Preschool, Cough, Female, Humans, Infant, Male, Respiration Disorders, Respiratory Sounds
Abstract

OBJECTIVE: To evaluate the impact of exposure to indoor air pollution on respiratory health outcomes (healthcare utilization, symptoms, medication use) in infants and children with bronchopulmonary dysplasia (BPD).

STUDY DESIGN: A total of 244 subjects were included from the Johns Hopkins Bronchopulmonary Dysplasia registry. Parents completed an environmental exposure questionnaire including secondhand smoke and indoor combustion (gas/propane heat, gas or wood stove, gas/wood burning fireplace) exposures in the home. Respiratory symptoms, both acute (healthcare utilization, steroid/antibiotic use) and chronic (cough/wheeze, nocturnal cough, use of beta-agonists, tolerance of physical activity), were also collected.

RESULTS: Three-quarters of the infants were exposed to at least 1 combustible source of air pollution in the home, and this exposure was associated with an increased risk of hospitalization in infants and children on home respiratory support. Only 14% of the study population reported secondhand smoke exposure, but we found that this was associated with chronic respiratory symptoms, including activity limitation and nocturnal cough. Infants on respiratory support also had increased daytime cough and wheezing. Approximately one-third reported having an air purifier in the home, and its presence attenuated the effect of secondhand smoke exposure on reported activity limitation.

CONCLUSIONS: Exposure to combustible sources of indoor air pollution was associated with increased respiratory morbidity in a group of high risk of infants with BPD. Our results support that indoor air pollution is a modifiable risk factor for respiratory health in infants with BPD.

DOI10.1016/j.jpeds.2020.03.010
Alternate JournalJ Pediatr
PubMed ID32417083
PubMed Central IDPMC7321913
Grant ListK23 ES029985 / ES / NIEHS NIH HHS / United States
R01 HL114800 / HL / NHLBI NIH HHS / United States