The Impact of Sex and Gender on Clinical Care and Research Design in Nephrolithiasis.

TitleThe Impact of Sex and Gender on Clinical Care and Research Design in Nephrolithiasis.
Publication TypeJournal Article
Year of Publication2021
AuthorsEllison JS, Tasian GE
JournalUrology
Volume151
Pagination54-57
Date Published2021 05
ISSN1527-9995
KeywordsFemale, Humans, Male, Nephrolithiasis, Research Design, Sex Factors
Abstract

Although classically a disease of male preponderance, scrutiny of the available data on nephrolithiasis reveals substantial epidemiological discrepancies between males and females, suggesting sex-based pathophysiology underlying this disease. Furthermore, sex-based differences may exist in underlying urinary risk factors, presentation, and treatment response. Recognizing these differences will be essential to further understand the multitude of etiologies of kidney stone disease and aid in developing appropriately designed comparative effectiveness trials.

DOI10.1016/j.urology.2020.04.089
Alternate JournalUrology
PubMed ID32387245