Height of fever and invasive bacterial infection.

TitleHeight of fever and invasive bacterial infection.
Publication TypeJournal Article
Year of Publication2020
AuthorsMichelson KA, Neuman MI, Pruitt CM, Desai S, Wang ME, DePorre AG, Leazer RC, Sartori LF, Marble RD, Rooholamini SN, Woll C, Balamuth F, Aronson PL
Corporate AuthorsFebrile Young Infant Research Collaborative
JournalArch Dis Child
Date Published2020 Aug 20

OBJECTIVE: We aimed to evaluate the association of height of fever with invasive bacterial infection (IBI) among febrile infants <=60 days of age.

METHODS: In a secondary analysis of a multicentre case-control study of non-ill-appearing febrile infants <=60 days of age, we compared the maximum temperature (at home or in the emergency department) for infants with and without IBI. We then computed interval likelihood ratios (iLRs) for the diagnosis of IBI at each half-degree Celsius interval.

RESULTS: The median temperature was higher for infants with IBI (38.8°C; IQR 38.4-39.2) compared with those without IBI (38.4°C; IQR 38.2-38.9) (p<0.001). Temperatures 39°C-39.4°C and 39.5°C-39.9°C were associated with a higher likelihood of IBI (iLR 2.49 and 3.40, respectively), although 30.4% of febrile infants with IBI had maximum temperatures <38.5°C.

CONCLUSIONS: Although IBI is more likely with higher temperatures, height of fever alone should not be used for risk stratification of febrile infants.

Alternate JournalArch. Dis. Child.
PubMed ID32819913
Grant ListK08 HS026006 / HS / AHRQ HHS / United States
K08 HS026503 / HS / AHRQ HHS / United States
KL2 TR001862 / TR / NCATS NIH HHS / United States