Heart Transplantation-The Pediatric Cardiac Critical Care Perspective.

TitleHeart Transplantation-The Pediatric Cardiac Critical Care Perspective.
Publication TypeJournal Article
Year of Publication2016
AuthorsRossano JW, Cabrera AG, Shaddy RE
JournalPediatr Crit Care Med
Volume17
Issue8_suppl Suppl 1
PaginationS171-S177
Date Published2016 Aug
ISSN1529-7535
Abstract

OBJECTIVES: Although there have been tremendous advancements in the care of severe pediatric cardiovascular disease, heart transplantation remains the standard therapy for end-stage heart disease in children. As such, these patients comprise an important and often complex subset of patients in the ICU. The purpose of this article is to review the causes and management of allograft dysfunction and the medications used in the transplant population.

DATA SOURCES: MEDLINE, PubMed, and Cochrane Database of systemic reviews.

CONCLUSIONS: Pediatric heart transplant recipients represent a complex group of patients that frequently require critical care. Their immunosuppressive medications, while being vital to maintenance of allograft function, are associated with significant short- and long-term complications. Graft dysfunction can occur from a variety of etiologies at different times following transplantation and remains a major limitation to long-term posttransplant survival.

DOI10.1097/PCC.0000000000000813
Alternate JournalPediatr Crit Care Med
PubMed ID27490596