- Research Methods &
- Research Training
- Research Into
|Title||Heart Retransplant Recipients Have Better Survival With Concurrent Kidney Transplant Than With Heart Retransplant Alone.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Savla J, Lin KY, Pradhan M, Ruebner RL, Rogers RS, Haskins SS, Owens AT, Abt PL, J Gaynor W, Shaddy RE, Rossano JW|
|Journal||J Am Heart Assoc|
|Date Published||2015 Dec|
|Keywords||Adult, Age Factors, Female, Glomerular Filtration Rate, Heart Transplantation, Humans, Kaplan-Meier Estimate, Kidney Diseases, Kidney Transplantation, Male, Middle Aged, Reoperation, Retrospective Studies, Risk Factors, Survival Analysis, Waiting Lists, Young Adult|
BACKGROUND: Heart retransplant (HRT) recipients represent a growing number of transplant patients. The impact of concurrent kidney transplants (KTs) in this population has not been well studied. We tested the hypothesis that recipients of HRT with concurrent KT (HRT-KT) would have worse survival than recipients of HRT alone.
METHODS AND RESULTS: A retrospective analysis of the United Network of Organ Sharing database was performed for all patients undergoing HRT from 1987 to 2011. There were 1660 HRT patients, of which 116 (7%) received concurrent KT. Those who received HRT-KT had older age, longer wait-list time, worse kidney function, and more known diabetes. Survival among recipients of HRT-KT was significantly better than that of recipients of HRT alone (P=0.005). A subgroup of 323 HRT patients with severe kidney dysfunction (estimated glomerular filtration rate <30 mL/min per 1.73 m(2) or on dialysis) was studied in more detail, and 76 (24%) received concurrent KT. Those on dialysis at the time of HRT had better survival with versus without concurrent KT (P<0.0001). On multivariable analysis, concurrent KT was independently associated with better outcomes for all patients with HRT and for the subgroup of patients with severe kidney dysfunction.
CONCLUSIONS: Recipients of HRT-KT have better survival than recipients of HRT alone. Further research is needed to determine which HRT patients may benefit the most from concurrent KT.
|Alternate Journal||J Am Heart Assoc|
|PubMed Central ID||PMC4845285|