Genetic syndromes associated with endocrine tumors in children.

TitleGenetic syndromes associated with endocrine tumors in children.
Publication TypeJournal Article
Year of Publication2020
AuthorsMacfarland S, Mostoufi-Moab S
JournalSemin Pediatr Surg
Volume29
Issue3
Pagination150919
Date Published2020 Jun
ISSN1532-9453
Abstract

Endocrine tumors comprise a variety of benign and malignant neoplasms that arise from the endocrine glands and neuroendocrine tissues. Functioning tumors are associated with typical clinical syndromes related to specific hormone(s) secreted, whereas nonfunctioning tumors present incidentally or secondary to symptoms related to mass effect. Endocrine tumors represent a minority of all neoplasms observed in the pediatric population and are generally associated with underlying hereditary syndromes. While most are clinically benign or low-grade cancers, a small percentage of endocrine tumors are high-grade malignancies requiring multimodal therapies. As with any rare childhood disease, treatment is best provided at tertiary care centers with multidisciplinary expertise in the management of such tumors.

DOI10.1016/j.sempedsurg.2020.150919
Alternate JournalSemin. Pediatr. Surg.
PubMed ID32571504