FDG-PET in two cases of neurofibromatosis type 1 and atypical malignancies.

TitleFDG-PET in two cases of neurofibromatosis type 1 and atypical malignancies.
Publication TypeJournal Article
Year of Publication2014
Authorsde Blank P, Cole K, Kersun LS, Green A, Wilkes JJ, Belasco J, Bagatell R, L Bailey C, Fisher MJ
JournalCurr Oncol
Volume21
Issue2
Paginatione345-8
Date Published2014 Apr
ISSN1198-0052
Abstract

Patients with neurofibromatosis type 1 (nf1) are at increased risk for both benign and malignant tumours, and distinguishing the malignant potential of an individual tumour is a common clinical problem in these patients. Here, we review two cases of uncommon malignancies (Hodgkin lymphoma and mediastinal germ-cell tumour) in patients with nf1. Although (18)F-fluorodeoxyglucose positron-emission tomography (fdg-pet) has been used to differentiate benign neurofibromas from malignant peripheral nerve sheath tumours, fdg-pet characteristics for more rare tumours have been poorly described in children with nf1. Here, we report the role of pet imaging in clinical decision-making in each case. In nf1, fdg-pet might be useful in the clinical management of unusual tumour presentations and might help to provide information about the malignant potential of uncommon tumours.

DOI10.3747/co.21.1803
Alternate JournalCurr Oncol
PubMed ID24764718
PubMed Central IDPMC3997466