Exercise capacity in the Fontan circulation.

TitleExercise capacity in the Fontan circulation.
Publication TypeJournal Article
Year of Publication2013
AuthorsGoldberg DJ, Avitabile CM, McBride MG, Paridon SM
JournalCardiol Young
Volume23
Issue6
Pagination824-30
Date Published2013 Dec
ISSN1467-1107
KeywordsAdolescent, Adult, Child, Exercise Tolerance, Fontan Procedure, Humans, Young Adult
Abstract

The Fontan operation can create a stable circulation from childhood through early adulthood. However, the absence of a sub-pulmonary pumping chamber leads to a physiology in which exercise capacity is limited and decreases with age starting in adolescence. The limitation in exercise capacity is more pronounced at peak levels of exercise, but is still present during more modest levels of activity. The underlying causes of exercise impairment relate to both central cardiovascular factors (oxygen delivery) and peripheral factors (oxygen extraction). Interventions to improve cardiac preload and to improve lean muscle mass may help to improve exercise capacity and, perhaps, will alter the "natural history" of the progressive decline.

DOI10.1017/S1047951113001649
Alternate JournalCardiol Young
PubMed ID24401254