Establishing a high-risk neuroblastoma cohort using the Pediatric Health Information System Database.

TitleEstablishing a high-risk neuroblastoma cohort using the Pediatric Health Information System Database.
Publication TypeJournal Article
Year of Publication2014
AuthorsDesai AV, Kavcic M, Huang YS, Herbst N, Fisher BT, Seif AE, Li Y, Hennessy S, Aplenc R, Bagatell R
JournalPediatr Blood Cancer
Volume61
Issue6
Pagination1129-31
Date Published2014 Jun
ISSN1545-5017
KeywordsAdolescent, Adult, Algorithms, Antineoplastic Agents, Cancer Care Facilities, Child, Child, Preschool, Cohort Studies, Databases, Factual, Drug Utilization, Female, Health Information Systems, Health Resources, Hospitals, Pediatric, Humans, Infant, Inpatients, International Classification of Diseases, Male, Neuroblastoma, Prescription Fees, Risk, Tertiary Care Centers, United States, Young Adult
Abstract

International Classification of Diseases, 9th Revision (ICD-9) code(s) for neuroblastoma do not exist, preventing identification of these patients in administrative databases. To overcome this challenge, a three-step algorithm, using ICD-9 codes, exclusion criteria, and manual review of chemotherapy billing data, was utilized to assemble a high-risk neuroblastoma cohort (n = 952) from the Pediatric Health Information System (PHIS) Database and validated at a single institution [sensitivity 89.1%; positive predictive value (PPV) 96.1%]. This cohort provides a data source for future comparative effectiveness and clinical epidemiology studies in high-risk neuroblastoma patients.

DOI10.1002/pbc.24930
Alternate JournalPediatr Blood Cancer
PubMed ID24616331
PubMed Central IDPMC4323158
Grant ListR01 CA165277 / CA / NCI NIH HHS / United States
R01CA165277 / CA / NCI NIH HHS / United States
T32 HD064567 / HD / NICHD NIH HHS / United States
T32-HD-06456702 / HD / NICHD NIH HHS / United States