Epidemiology of Invasive Fungal Disease in Children.

TitleEpidemiology of Invasive Fungal Disease in Children.
Publication TypeJournal Article
Year of Publication2017
AuthorsPana ZDorothea, Roilides E, Warris A, Groll AH, Zaoutis TE
JournalJ Pediatric Infect Dis Soc
Volume6
Issuesuppl_1
PaginationS3-S11
Date Published2017 Sep 01
ISSN2048-7207
Abstract

Considerable progress has been made in the prevention, diagnosis, and management of pediatric patients with invasive fungal disease (IFD). The reported decreasing trend in the incidence of invasive candidiasis (IC) over the past 15 years in both neonates and children has been encouraging. Nevertheless, due to the growing number of immunocompromised children at risk for IFD, this disease continues to be associated with significant morbidity and death and with increased financial burden to the health care system. Therefore, it is important to understand the contemporary epidemiology of IFD. Incidence rates of IFD in children are affected by geographical, population, and time variability. There is an ongoing effort to constantly document and update the incidence of IFD and species distribution among different pediatric populations as a means to direct preventative, diagnostic, and therapeutic resources to the most appropriate subset of patients. Children with a hematologic malignancy or a primary or secondary immunodeficiency, those undergoing solid organ or hematopoietic stem cell transplantation, and premature neonates are the major subsets of pediatric patients at risk of developing IFD. In this review, we focus on fungal disease epidemiology with a specific emphasis on the 2 most common pediatric IFDs, IC and invasive aspergillosis (IA).

DOI10.1093/jpids/pix046
Alternate JournalJ Pediatric Infect Dis Soc
PubMed ID28927200