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|Title||Epidemiology of infections and antimicrobial use in Greek Neonatal Units.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Gkentzi D, Kortsalioudaki C, Cailes BC, Zaoutis TE, Kopsidas J, Tsolia M, Spyridis N, Siahanidou S, Sarafidis K, Heath PT, Dimitriou G|
|Corporate Authors||Neonatal Infection Surveillance Network in Greece|
|Journal||Arch Dis Child Fetal Neonatal Ed|
|Date Published||2018 Jun 28|
OBJECTIVE: To describe the epidemiology of neonatal infections and of antimicrobial use in Greek Neonatal Units (NNUs) in order to develop national, evidence-based guidelines on empiric antimicrobial use for neonatal sepsis in Greece.
DESIGN: Retrospective analysis of prospectively collected infection surveillance data from 2012 to 2015, together with a Point Prevalence Survey (PPS) on antimicrobial use and the collection of data on local empiric antimicrobial policies.
SETTING: 16 NNUs in Greece participating in the neonIN infection surveillance network PATIENTS: Newborns in participating NNUs who had a positive blood, cerebrospinal fluid or urine culture and were treated with at least 5 days of antibiotics.
RESULTS: 459 episodes were recorded in 418 infants. The overall incidence of infection was 50/1000 NNU-admissions. The majority of episodes were late-onset sepsis (LOS) (413, 90%). (80%) were the most common Gram-positive organisms causing LOS and spp (39%) the most common Gram-negative. Nearly half (45%) of the spp were resistant to at least one aminoglycoside. The PPS revealed that 196 of 484 (40%) neonates were on antimicrobials. The survey revealed wide variation in empiric antimicrobial policies for LOS.
CONCLUSIONS: This is the largest collection of data on the epidemiology of neonatal infections in Greece and on neonatal antimicrobial use. It provides the background for the development of national evidence-based guidelines. Continuous surveillance, the introduction of antimicrobial stewardship interventions and evidence-based guidelines are urgently required.
|Alternate Journal||Arch. Dis. Child. Fetal Neonatal Ed.|