Epidemiology of childhood acute myeloid leukemia.

TitleEpidemiology of childhood acute myeloid leukemia.
Publication TypeJournal Article
Year of Publication2013
AuthorsPuumala SE, Ross JA, Aplenc R, Spector LG
JournalPediatr Blood Cancer
Date Published2013 May
KeywordsAdolescent, Birth Order, Birth Weight, Breast Feeding, Child, Child, Preschool, Environmental Exposure, Humans, Infant, Infant, Newborn, Leukemia, Myeloid, Acute, Maternal Age, Polymorphism, Single Nucleotide, Risk Factors

Although leukemia is the most common childhood cancer diagnosis, the subtype, acute myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review summarizes the major risk factors for AML. We searched the literature using PubMed for articles on childhood AML and reviewed 180 articles. While few risk factors are definitive, we identified several with consistent evidence of a possible effect. Thorough analysis of genetic and epigenetic factors is missing from this literature and methodological issues are unresolved. Future studies should more closely examine causal mechanisms, improve exposure measurement, and include analysis using genetic and epigenetic factors.

Alternate JournalPediatr Blood Cancer
PubMed ID23303597
PubMed Central IDPMC3664189
Grant ListK05 CA157439 / CA / NCI NIH HHS / United States
K05 CA157439 / CA / NCI NIH HHS / United States
R01 CA133881 / CA / NCI NIH HHS / United States