Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation.

TitleEpidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation.
Publication TypeJournal Article
Year of Publication2012
AuthorsFisher BT, Alexander S, Dvorak CC, Zaoutis TE, Zerr DM, Sung L
JournalPediatr Blood Cancer
Volume59
Issue1
Pagination11-5
Date Published2012 Jul 15
ISSN1545-5017
KeywordsAdolescent, Child, Child, Preschool, Female, Hematopoietic Stem Cell Transplantation, Humans, Infection Control, Male, Neoplasms, Virus Diseases
Abstract

In pediatric patients with malignancy and those receiving hematopoietic stem cell transplants, bacterial and fungal infections have been the focus of fever and neutropenia episodes for decades. However, improved diagnostic capabilities have revealed viral pathogens as a significant cause of morbidity and mortality. Because of limited effective antiviral therapies, prevention of viral infections is paramount. Pre-exposure and post-exposure prophylaxis and antiviral suppressive therapeutic approaches are reviewed. Additionally, infection control practices specific to this patient population are discussed. A comprehensive approach utilizing each of these can be effective at reducing the negative impact of viral infections.

DOI10.1002/pbc.23417
Alternate JournalPediatr Blood Cancer
PubMed ID22102619
PubMed Central IDPMC4008326
Grant ListU10 CA095861 / CA / NCI NIH HHS / United States
U10 CA098543 / CA / NCI NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada