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|Title||Eosinophilic Esophagitis Is a Late Manifestation of the Allergic March.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Hill DA, Grundmeier RW, Ramos M, Spergel JM|
|Journal||J Allergy Clin Immunol Pract|
|Date Published||2018 Jun 13|
BACKGROUND: The allergic march describes the natural history of allergic conditions as they develop during childhood. Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease that can be triggered by specific foods. Despite its allergic pathophysiology, the epidemiologic relationship between EoE and established members of the allergic march is unknown.
OBJECTIVE: We sought to determine whether EoE meets epidemiologic criteria for being considered a member of the allergic march.
METHODS: Using a primary care birth cohort of 130,435 children, we determined the natural histories of atopic dermatitis (AD), IgE-mediated food allergy (IgE-FA), asthma, EoE, and allergic rhinitis (AR) in individual patients. We then performed case-control analyses to establish the extent that existing allergic conditions influence the rate of subsequent EoE diagnosis.
RESULTS: A total of 139 children developed EoE during the observation period (prevalence of 0.11%). The peak age of EoE diagnosis was 2.6 years, as compared with 0.3 years, 1 year, 1.1 years, and 2.1 years for AD, IgE-FA, asthma, and AR, respectively. The presence of AD (hazard ratio [HR] 3.2, 95% confidence interval [CI] 2.2-4.6), IgE-FA (HR 9.1, 95% CI 6.5-12.6), and asthma (HR 1.9, 95% CI 1.3-2.7) was independently and cumulatively associated with subsequent EoE diagnosis. The presence of AR was associated with subsequent EoE diagnosis (HR 2.8, 95% CI 2.0-3.9), and the presence of EoE was associated with subsequent AR diagnosis (HR 2.5, 95% CI 1.7-3.5).
CONCLUSIONS: Allergic comorbidities are positively associated with EoE diagnosis. Together, our findings suggest that EoE is a late manifestation of the allergic march.
|Alternate Journal||J Allergy Clin Immunol Pract|
|Grant List||T32 HD043021 / HD / NICHD NIH HHS / United States|