Title | Enthesitis is an extraintestinal manifestation of pediatric inflammatory bowel disease. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Horton DB, Sherry DD, Baldassano RN, Weiss PF |
Journal | Ann Paediatr Rheumatol |
Volume | 1 |
Issue | 4 |
Date Published | 2012 Jan |
ISSN | 2146-2909 |
Abstract | BACKGROUND: Enthesitis is an extra-intestinal manifestation of inflammatory bowel disease (IBD) in adults. However, little has been published about the prevalence or characteristics of enthesitis in pediatric IBD. METHODS: We conducted a cross-sectional study of children and young adults ages 4-21 years with IBD. Subjects were recruited among those receiving routine care in a gastroenterology clinic. All subjects underwent a clinical examination of the entheses and joints, and completed a study questionnaire. RESULTS: We enrolled 43 subjects, who had a median age of 16 years and a median time from IBD diagnosis of 2.7 years. 32 subjects (74%) had Crohn disease, 10 subjects (23%) had indeterminate colitis, and 1 subject (2%) had ulcerative colitis. At least one tender enthesis was present in 21% of subjects and 12% had more than 2 tender entheses. The most commonly affected entheses were located at the inferior patella, the femoral greater trochanter, and the proximal humerus. The presence of enthesitis was associated with a higher intensity of recent musculoskeletal pain (p=0.03). CONCLUSIONS: Enthesitis is a prevalent extra-intestinal manifestation of pediatric IBD and is associated with increased musculoskeletal pain. Future studies should evaluate the functional and long-term impact of enthesitis on children with IBD. |
DOI | 10.5455/apr.102920121510 |
Alternate Journal | Ann Paediatr Rheumatol |
PubMed ID | 24349861 |
PubMed Central ID | PMC3860180 |
Grant List | K23 AR059749 / AR / NIAMS NIH HHS / United States |