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|Title||Enthesitis is an extraintestinal manifestation of pediatric inflammatory bowel disease.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Horton DB, Sherry DD, Baldassano RN, Weiss PF|
|Journal||Ann Paediatr Rheumatol|
|Date Published||2012 Jan|
BACKGROUND: Enthesitis is an extra-intestinal manifestation of inflammatory bowel disease (IBD) in adults. However, little has been published about the prevalence or characteristics of enthesitis in pediatric IBD.
METHODS: We conducted a cross-sectional study of children and young adults ages 4-21 years with IBD. Subjects were recruited among those receiving routine care in a gastroenterology clinic. All subjects underwent a clinical examination of the entheses and joints, and completed a study questionnaire.
RESULTS: We enrolled 43 subjects, who had a median age of 16 years and a median time from IBD diagnosis of 2.7 years. 32 subjects (74%) had Crohn disease, 10 subjects (23%) had indeterminate colitis, and 1 subject (2%) had ulcerative colitis. At least one tender enthesis was present in 21% of subjects and 12% had more than 2 tender entheses. The most commonly affected entheses were located at the inferior patella, the femoral greater trochanter, and the proximal humerus. The presence of enthesitis was associated with a higher intensity of recent musculoskeletal pain (p=0.03).
CONCLUSIONS: Enthesitis is a prevalent extra-intestinal manifestation of pediatric IBD and is associated with increased musculoskeletal pain. Future studies should evaluate the functional and long-term impact of enthesitis on children with IBD.
|Alternate Journal||Ann Paediatr Rheumatol|
|PubMed Central ID||PMC3860180|
|Grant List||K23 AR059749 / AR / NIAMS NIH HHS / United States|