Enthesitis is an extraintestinal manifestation of pediatric inflammatory bowel disease.

TitleEnthesitis is an extraintestinal manifestation of pediatric inflammatory bowel disease.
Publication TypeJournal Article
Year of Publication2012
AuthorsHorton DB, Sherry DD, Baldassano RN, Weiss PF
JournalAnn Paediatr Rheumatol
Date Published2012 Jan

BACKGROUND: Enthesitis is an extra-intestinal manifestation of inflammatory bowel disease (IBD) in adults. However, little has been published about the prevalence or characteristics of enthesitis in pediatric IBD.

METHODS: We conducted a cross-sectional study of children and young adults ages 4-21 years with IBD. Subjects were recruited among those receiving routine care in a gastroenterology clinic. All subjects underwent a clinical examination of the entheses and joints, and completed a study questionnaire.

RESULTS: We enrolled 43 subjects, who had a median age of 16 years and a median time from IBD diagnosis of 2.7 years. 32 subjects (74%) had Crohn disease, 10 subjects (23%) had indeterminate colitis, and 1 subject (2%) had ulcerative colitis. At least one tender enthesis was present in 21% of subjects and 12% had more than 2 tender entheses. The most commonly affected entheses were located at the inferior patella, the femoral greater trochanter, and the proximal humerus. The presence of enthesitis was associated with a higher intensity of recent musculoskeletal pain (p=0.03).

CONCLUSIONS: Enthesitis is a prevalent extra-intestinal manifestation of pediatric IBD and is associated with increased musculoskeletal pain. Future studies should evaluate the functional and long-term impact of enthesitis on children with IBD.

Alternate JournalAnn Paediatr Rheumatol
PubMed ID24349861
PubMed Central IDPMC3860180
Grant ListK23 AR059749 / AR / NIAMS NIH HHS / United States