Elevated Pre-Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection.

TitleElevated Pre-Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection.
Publication TypeJournal Article
Year of Publication2017
AuthorsRavimohan S, Tamuhla N, Nfanyana K, Ni H, Steenhoff AP, Gross R, Weissman D, Bisson GP
JournalClin Infect Dis
Volume64
Issue10
Pagination1453-1456
Date Published2017 May 15
ISSN1537-6591
KeywordsAdult, Aged, Anti-Retroviral Agents, Antigens, CD, Antiretroviral Therapy, Highly Active, Apyrase, Biomarkers, Botswana, CD4 Lymphocyte Count, CD8-Positive T-Lymphocytes, Cohort Studies, Coinfection, Female, HIV Infections, Humans, Male, Middle Aged, Prospective Studies, Tuberculosis, Young Adult
Abstract

Correlates of death soon after antiretroviral therapy (ART) initiation remain unclear. We investigated the association between expression of CD39, a novel immune exhaustion marker, and early mortality in patients with human immunodeficiency virus/tuberculosis co-infection. Elevated pre-ART CD39+CD8+ T cell frequency was independently associated with mortality within 6 months of ART initiation.

DOI10.1093/cid/cix155
Alternate JournalClin. Infect. Dis.
PubMed ID28203772
PubMed Central IDPMC5411394
Grant ListKL2 TR001879 / TR / NCATS NIH HHS / United States