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|Title||Early childhood antibiotic utilization for infants discharged from the neonatal intensive care unit.|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||Flannery DD, Passarella M, Mukhopadhyay S, Dhudasia MB, Gerber JS, Lorch SA, Hennessy S, Puopolo KM|
|Date Published||2022 Apr 05|
OBJECTIVE: To determine antibiotic utilization for NICU infants, as compared to non-NICU infants, in the first 3 years after birth hospital discharge.
STUDY DESIGN: Retrospective observational study using data from Medicaid Analytic Extract including 667 541 newborns discharged from 2007-2011. Associations between NICU admission and antibiotic prescription were assessed using regression models, adjusting for confounders, and stratified by gestational age and birth weight.
RESULTS: 596 999 infants (89.4%) received ≥1 antibiotic, with a median of 4 prescriptions per 3 person-years (IQR 2-8). Prescribed antibiotics and associated indication were similar between groups. Compared to non-NICU infants (N = 586 227), NICU infants (N = 81 314) received more antibiotic prescriptions (adjusted incidence rate ratio 1.08, 95% confidence interval [CI] (1.08,1.08)). Similar results were observed in all NICU subgroups.
CONCLUSIONS: Antibiotic utilization in early childhood was higher among infants discharged from NICUs compared to non-NICU infants.
|Alternate Journal||J Perinatol|
|Grant List||K08HS027468 / / U.S. Department of Health & Human Services | Agency for Healthcare Research and Quality (AHRQ) /|