Development of new strategies for early diagnosis of mucormycosis from bench to bedside.

TitleDevelopment of new strategies for early diagnosis of mucormycosis from bench to bedside.
Publication TypeJournal Article
Year of Publication2014
AuthorsWalsh TJ, Skiada A, Cornely OA, Roilides E, Ibrahim A, Zaoutis TE, Groll A, Lortholary O, Kontoyiannis DP, Petrikkos G
JournalMycoses
Volume57 Suppl 3
Pagination2-7
Date Published2014 Dec
ISSN1439-0507
KeywordsAntifungal Agents, Databases, Factual, Diagnostic Imaging, Early Diagnosis, Humans, Microbiological Techniques, Mucorales, Mucormycosis, Registries, Risk Assessment, Societies, Scientific, Specimen Handling
Abstract

Early diagnosis and initiation of amphotericin B (AmB) for treatment of mucormycosis increases survival from approximately 40% to 80%. The central objective of a new study of the European Confederation of Medical Mycology (ECMM) and the International Society for Human and Animal Mycology (ISHAM) Zygomycosis Working Group is to improve the clinical and laboratory diagnosis of mucormycosis. The diagnostic tools generated from this study may help to significantly improve survival from mucormycosis worldwide. The study has three major objectives: to conduct a prospective international registration of patients with mucormycosis using a well-established global network of centres; to construct a predictive risk model for patients at risk for mucormycosis; and to establish an international archive of specimens of tissues, fluids, and organisms linked from the patients enrolled into the registry that will be used for development of leading edge molecular, proteomic, metabolic and antigenic systems for mucormycosis.

DOI10.1111/myc.12249
Alternate JournalMycoses
PubMed ID25475924
PubMed Central IDPMC4464811
Grant ListR01 AI063503 / AI / NIAID NIH HHS / United States