Daily mean temperature and clinical kidney stone presentation in five U.S. metropolitan areas: a time-series analysis.

TitleDaily mean temperature and clinical kidney stone presentation in five U.S. metropolitan areas: a time-series analysis.
Publication TypeJournal Article
Year of Publication2014
AuthorsTasian GE, Pulido JE, Gasparrini A, Saigal CS, Horton BP, J Landis R, Madison R, Keren R
Corporate AuthorsUrologic Diseases in America Project
JournalEnviron Health Perspect
Volume122
Issue10
Pagination1081-7
Date Published2014 Oct
ISSN1552-9924
KeywordsCities, Climate, Environmental Exposure, Female, Humans, Kidney Calculi, Male, Risk Factors, Temperature, Time Factors, United States
Abstract

BACKGROUND: High ambient temperatures are a risk factor for nephrolithiasis, but the precise relationship between temperature and kidney stone presentation is unknown.

OBJECTIVES: Our objective was to estimate associations between mean daily temperature and kidney stone presentation according to lag time and temperatures.

METHODS: Using a time-series design and distributed lag nonlinear models, we estimated the relative risk (RR) of kidney stone presentation associated with mean daily temperatures, including cumulative RR for a 20-day period, and RR for individual daily lags through 20 days. Our analysis used data from the MarketScan Commercial Claims database for 60,433 patients who sought medical evaluation or treatment of kidney stones from 2005-2011 in the U.S. cities of Atlanta, Georgia; Chicago, Illinois; Dallas, Texas; Los Angeles, California; and Philadelphia, Pennsylvania.

RESULTS: Associations between mean daily temperature and kidney stone presentation were not monotonic, and there was variation in the exposure-response curve shapes and the strength of associations at different temperatures. However, in most cases RRs increased for temperatures above the reference value of 10°C. The cumulative RR for a daily mean temperature of 30°C versus 10°C was 1.38 in Atlanta (95% CI: 1.07, 1.79), 1.37 in Chicago (95% CI: 1.07, 1.76), 1.36 in Dallas (95% CI: 1.10, 1.69), 1.11 in Los Angeles (95% CI: 0.73, 1.68), and 1.47 in Philadelphia (95% CI: 1.00, 2.17). Kidney stone presentations also were positively associated with temperatures < 2°C in Atlanta, and < 10°C in Chicago and Philadelphia. In four cities, the strongest association between kidney stone presentation and a daily mean temperature of 30°C versus 10°C was estimated for lags of ≤ 3 days.

CONCLUSIONS: In general, kidney stone presentations increased with higher daily mean temperatures, with the strongest associations estimated for lags of only a few days. These findings further support an adverse effect of high temperatures on nephrolithiasis.

DOI10.1289/ehp.1307703
Alternate JournalEnviron. Health Perspect.
PubMed ID25009122
PubMed Central IDPMC4181925
Grant ListG1002296 / / Medical Research Council / United Kingdom
G1002296 / / Medical Research Council / United Kingdom
N01-DK70003 / DK / NIDDK NIH HHS / United States
T32HD060550 / HD / NICHD NIH HHS / United States