Creation of a pediatric mature B-cell non-Hodgkin lymphoma cohort within the Pediatric Health Information System Database.

TitleCreation of a pediatric mature B-cell non-Hodgkin lymphoma cohort within the Pediatric Health Information System Database.
Publication TypeJournal Article
Year of Publication2017
AuthorsCitrin R, Horowitz JP, Reilly AF, Li Y, Huang YV, Getz KD, Seif AE, Fisher BT, Aplenc R
JournalPLoS One
Volume12
Issue10
Paginatione0186960
Date Published2017
ISSN1932-6203
Abstract

Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a collection of relatively rare pediatric malignancies. In order to utilize administrative data to perform large-scale epidemiologic studies within this population, a two-step process was used to assemble a 12-year cohort of B-NHL patients treated between 2004 and 2015 within the Pediatric Health Information System database. Patients were identified by ICD-9 codes, and their chemotherapy data were then manually reviewed against standard B-NHL treatment regimens. A total of 1,409 patients were eligible for cohort inclusion. This process was validated at a single center, utilizing both an institutional tumor registry and medical record review as the gold standards. The validation demonstrated appropriate sensitivity (91.5%) and positive predictive value (95.1%) to allow for the future use of this cohort for epidemiologic and comparative effectiveness research.

DOI10.1371/journal.pone.0186960
Alternate JournalPLoS ONE
PubMed ID29059235