Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome.

TitleConvalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome.
Publication TypeJournal Article
Year of Publication2020
AuthorsDiorio C, Anderson EM, McNerney KO, Goodwin EC, Chase JC, Bolton MJ, Arevalo CP, Weirick ME, Gouma S, Vella LA, Henrickson SE, Chiotos K, Fitzgerald JC, Kilbaugh TJ, John AROdom, Blatz AM, Lambert MP, Sullivan KE, Tartaglione MR, Zambrano D, Martin M, Lee JH, Young P, Friedman D, Sesok-Pizzini DA, Hensley SE, Behrens EM, Bassiri H, Teachey DT
JournalPediatr Blood Cancer
Paginatione28693
Date Published2020 Sep 04
ISSN1545-5017
Abstract

There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 (COVID-19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody-dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed.

DOI10.1002/pbc.28693
Alternate JournalPediatr Blood Cancer
PubMed ID32885904
Grant List / / Leukemia and Lymphoma Society /
/ / University of Pennsylvania /
/ / Kate Amato Foundation /
/ / American Academy of Allergy Asthma and Immunology /
/ / Cookies for Kids Cancer /
/ / Children's Oncology Group /
/ / Stand Up To Cancer /
/ / Alex's Lemonade Stand Foundation for Childhood Cancer /
K08AI135091 / NH / NIH HHS / United States
K08AI136660 / NH / NIH HHS / United States
K12HS026393 / NH / NIH HHS / United States
R01A1123538 / NH / NIH HHS / United States
R01AI103280 / NH / NIH HHS / United States
R01AI121250 / NH / NIH HHS / United States
R01AI123433 / NH / NIH HHS / United States
R01CA193776 / NH / NIH HHS / United States
R21AI144472 / NH / NIH HHS / United States
T32AI007324 / NH / NIH HHS / United States
UG1CA233249 / NH / NIH HHS / United States
X01HD100702 / NH / NIH HHS / United States
/ / Team Connor /
/ / Clinical Immunology Society /
Immune Dysregulation Frontier Program / / Children's Hospital of Philadelphia /
/ / Burroughs Wellcome Fund /