Complications preceding early deaths in Black and White children with acute myeloid leukemia.

TitleComplications preceding early deaths in Black and White children with acute myeloid leukemia.
Publication TypeJournal Article
Year of Publication2017
AuthorsWinestone LE, Getz KD, Miller TP, Li Y, Huang Y-S, Seif AE, Fisher BT, Aplenc R
JournalPediatr Blood Cancer
Date Published2017 Jul 20
ISSN1545-5017
Abstract

Black patients have a twofold increased risk of induction mortality compared to White patients with acute myeloid leukemia (AML). We reviewed diagnosis and billing data from Pediatric Health Information System for 28 AML Induction I deaths to investigate conditions preceding death in White and Black patients. Half of deaths occurred within 10 days of initial diagnostic admission. Respiratory, cardiac, renal, and infectious complications were common prior to both White and Black deaths. Deaths in White patients were more commonly preceded by intracranial hemorrhage compared to deaths in Black patients. Future studies should assess management approaches of complications by race to identify modifiable processes that reduce mortality.

DOI10.1002/pbc.26712
Alternate JournalPediatr Blood Cancer
PubMed ID28727288