Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.

TitleCollaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.
Publication TypeJournal Article
Year of Publication2015
AuthorsC Zwaan M, Kolb EA, Reinhardt D, Abrahamsson J, Adachi S, Aplenc R, De Bont ESJM, De Moerloose B, Dworzak M, Gibson BES, Hasle H, Leverger G, Locatelli F, Ragu C, Ribeiro RC, Rizzari C, Rubnitz JE, Smith OP, Sung L, Tomizawa D, van den Heuvel-Eibrink MM, Creutzig U, Kaspers GJL
JournalJ Clin Oncol
Volume33
Issue27
Pagination2949-62
Date Published2015 Sep 20
ISSN1527-7755
Abstract

Diagnosis, treatment, response monitoring, and outcome of pediatric acute myeloid leukemia (AML) have made enormous progress during the past decades. Because AML is a rare type of childhood cancer, with an incidence of approximately seven occurrences per 1 million children annually, national and international collaborative efforts have evolved. This overview describes these efforts and includes a summary of the history and contributions of each of the main collaborative pediatric AML groups worldwide. The focus is on translational and clinical research, which includes past, current, and future clinical trials. Separate sections concern acute promyelocytic leukemia, myeloid leukemia of Down syndrome, and relapsed AML. A plethora of novel antileukemic agents that have emerged, including new classes of drugs, are summarized as well. Finally, an important aspect of the treatment of pediatric AML--supportive care--and late effects are discussed. The future is bright, with a wide range of emerging innovative therapies and with more and more international collaboration that ultimately aim to cure all children with AML, with fewer adverse effects and without late effects.

DOI10.1200/JCO.2015.62.8289
Alternate JournalJ. Clin. Oncol.
PubMed ID26304895
PubMed Central IDPMC4567700
Grant ListU10-CA098413 / CA / NCI NIH HHS / United States
U10-CA098543 / CA / NCI NIH HHS / United States
U10-CA180886 / CA / NCI NIH HHS / United States
U10-CA180899 / CA / NCI NIH HHS / United States