CLL/SLL diagnosed in an adolescent.

TitleCLL/SLL diagnosed in an adolescent.
Publication TypeJournal Article
Year of Publication2014
AuthorsLuskin M, Wertheim G, Morrissette J, Daber R, Biegel J, Wilmoth DM, Kersun L, King R, Paessler M, Simon C, Aplenc R, Loren A
JournalPediatr Blood Cancer
Volume61
Issue6
Pagination1107-10
Date Published2014 Jun
ISSN1545-5017
KeywordsAdolescent, Age Factors, Ataxia Telangiectasia Mutated Proteins, Biomarkers, Tumor, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 8, Diagnostic Imaging, Gene Dosage, Genes, myc, Humans, Immunophenotyping, In Situ Hybridization, Fluorescence, Leukemia, Lymphocytic, Chronic, B-Cell, Lymph Nodes, Male, Sequence Deletion
Abstract

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a disease of older adults. Pediatric CLL/SLL is vanishingly rare in the literature. We present a case of CLL/SLL diagnosed in a 17-year-old male. The pathologic findings of this case were those of classic CLL/SLL with an ATM deletion, a characteristic genetic abnormality in CLL/SLL. Management guidelines for CLL/SLL are tailored to older adults making determination of the optimal therapy for this patient a unique challenge.

DOI10.1002/pbc.24884
Alternate JournalPediatr Blood Cancer
PubMed ID24281971