Children with lower respiratory tract infections and serum 25-hydroxyvitamin D3 levels: A case-control study.

TitleChildren with lower respiratory tract infections and serum 25-hydroxyvitamin D3 levels: A case-control study.
Publication TypeJournal Article
Year of Publication2016
AuthorsLópez AAlfonso Ve, Gerber JS, Leonard MB, Xie D, Schinnar R, Strom BL
JournalPediatr Pulmonol
Date Published2016 May 1
ISSN1099-0496
Abstract

BACKGROUND: Pneumonia is the leading cause of death in children under age of 5 years worldwide. The role of vitamin D in respiratory infections including pneumonia is unclear; therefore, we aimed to determine if children with lower respiratory tract infections had low serum 25-hydroxyvitamin D3 .

METHODS: We performed a case-control study of children ages 3-60 months from the Guatemala City metropolitan area, hospitalized with community-acquired pneumonia between September and December 2012. Controls were selected from the well-baby/care immunization clinics serving the population from which cases emerged. We analyzed serum 25-hydroxyvitamin D3 levels and conducted parental interviews to assess subject age, sex, race, feeding type, vitamin D supplementation, frequency of sun exposure, and maternal education. Height and weight were ascertained from medical records. Complete information was available for 70 (83%) of 84 eligible cases and 68 (60%) of 113 eligible controls.

RESULTS: The median (IQR) serum 25-hydroxyvitamin D3 concentration for cases was 23.2 ng/ml (14.4-29.9) compared to 27.5 ng/ml (21.4-32.3) in controls (P = 0.006). Multiple regression analysis using an a priori cut-point for vitamin D of <20 ng/ml showed that children with lower respiratory tract infections were more likely to have low 25-hydroxyvitamin D3 levels than controls (adjusted odds ratio 2.4, 95% confidence interval 1.1-5.2, P = 0.02).

CONCLUSIONS: Children with lower respiratory tract infections in Guatemala had low 25-hydroxyvitamin D3 levels. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc.

DOI10.1002/ppul.23439
Alternate JournalPediatr. Pulmonol.
PubMed ID27133156